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Lisa M. Utschig

Photosynthesis Group
Argonne National Laboratory
Chemistry Division, E109
9700 South Cass Avenue
Argonne, IL 60439
Phone: 630-252-3544
Fax: 630-252-9289
E-mail: utschig@anl.gov

Education

Ph.D., Inorganic Chemistry, Northwestern University,
Evanston, IL - June 1995

M.S. (non-thesis), Inorganic Chemistry, Northwestern University,
Evanston, IL - December 1991

B.A., Chemistry, (Magna Cum Laude), Cornell College,
Mt. Vernon, IA - May 1990

Honors and Activities

  • Argonne Pacesetter Award, 2007
  • Enrico Fermi Scholar, 1995 - 1997
  • NIH National Research Service Award Training Grant
    in Molecular Biophysics, 1992-1994
  • Phi Lamba Upsilon, 1991-Present
  • National Science Foundation Honorable Mention, 1991
  • Departmental Fellowship, 1990-Present
  • Phi Beta Kappa, Elected Member 1990
  • The American Institute of Chemists Foundation
    Student Award, 1990
  • ACS Analytical Chemistry Student Award, 1989
  • Arthur E. Lowell Scholarship for Leadership and
    Academic Excellence, 1988-1990
  • CRC Outstanding Freshman Chemistry Award, 1987
  • William Fletcher King Scholarship for Academic
    Potential, 1986-1990
  • Graduated Salutatorian, 1986

Research Experience

2003-present  Chemist, Chemistry Division, Argonne National Laboratory
1998-2002      Assistant Scientist, Chemistry Division, Argonne National Laboratory
1995-1997      Enrico Fermi Scholar, Chemistry Division, Argonne National Laboratory 1990-1995      Ph.D. Thesis Research, Northwestern University, Evanston, IL
                        Thesis title: "Heavy Metal Recognition by the MerR Metalloregulatory
                        Protein and Mercury-199 NMR Methods as Spectroscopic Probes of                         Metalloproteins."         Advisor: Professor Thomas V. O'Halloran
1989-1990      Summer Undergraduate Research Fellowship (SURF), University of
                        Iowa, Iowa City, IA

Teaching Experience

  • Visiting Lecturer, Cornell College, Mt. Vernon, IA
    General Chemistry, One-Course-at-a-Time curriculum, Nov. 1994
  • Teaching Assistant, Northwestern University, Evanston, IL
    General Chemistry Laboratory, 1989-1990
    Physical Chemistry Advanced Spectroscopy Lab, 1992-1994

Publications

  1. Magnetic Resonance Spectroscopy, Calcium Content, and Anion
    Coordination Studies of Bovine and Goat Lactoperoxidase, G. S. Lukat,
    M. B. Doran, L. M. Utschig and H. M. Goff, J. Inorg. Biochem. 1993,
    50, 157.
  2. Biochemical and Spectroscopic Probes of Hg(II) Coordination
    Environments in Proteins, L. M. Utschig, J. G. Wright and T. V. O'Halloran,
    In Methods in Enzymology, edited by B. Vallee and J. Riordan, Academic
    Press: San Diego, 1993; Vol. 226; pp 71-97.
  3. Structural Characterization of the Binding-Site in the MerR
    Metalloregulatory Protein, K. Clark, L. Utschig, T. V. O'Halloran and
    J. E. Penner-Hahn, Japanese J. Appl. Physics, 1993, 32, 536.
  4. The 199Hg Chemical Shift as a Probe of Coordination Environments
    in Blue Copper Proteins, L. M. Utschig, J. G. Wright, G. Dieckmann,
    V. Pecoraro and T. V. O'Halloran, Inorg. Chem. 1995, 34, 2497-2498.
  5. Mercury-199NMR of the Metal Receptor Site in MerR and its Protein-
    DNA Complex, L. M. Utschig, J. W. Bryson and T. V. O'Halloran,
    Science, 1995, 268, 380-385.
  6. Probing Copper-Thioether Coordination Chemistry in Rusticyanin and
    Azurin by 2D 1H-199Hg NMR, L. M. Utschig, T. Baynard,
    C. Strong and T. V. O'Halloran, Inorg. Chem, 1997, 36, 2926-2927.
  7. Mercury-Responsive Gene Regulation and Mercury-199 as a Probe
    of Protein Structures, D. L Huffman, L. M Utschig and T. V. O'Halloran,
    in Metal Ions in Biological Systems, edited by A. Sigel and H. Sigel,
    Marcel Dekker: New York, 1997, Vol. 34.
  8. The De Novo Design of Mercury-Binding Two- and Three-Helical
    Bundles, G. R. Dieckmann, D. L. Tierney, L. M. Utschig, D. K. McRorie,
    T. V. O'Halloran, J. E. Penner-Hahn, W. F. DeGrado and V. L. Pecoraro,
    JACS, 1997, 119, 6195-6196.
  9. Influence of Iron-Removal Procedures on Sequential Electron
    Transfer in Photosynthetic Bacterial Reaction Centers Studied by
    Transient EPR Spectroscopy, L. M. Utschig, S. R. Greenfield, J. Tang,
    P. D. Laible and M. C. Thurnauer, Biochem., 1997, 36, 8548-8558.
  10. Discovery of a New Metal-Binding Site in Photosynthetic Bacterial
    Reaction Centers that Modulates QA to QB Electron Transfer,
    L. M. Utschig, Y. Ohigashi, M. C. Thurnauer and D. M. Tiede,
    Biochem., 1998, 37, 8278-8281.
  11. Paramagnetic Rh(III) Complexes from Reactions of Phosphines
    with Hydride-Bridged and Nonbridged Rhodium Phthalocyanine
    Dimers: Metal-to-Ligand Charge Transfer Induced by Phosphines,
    M. J. Chen, L. M. Utschig, and J. W. Rathke, Inorg. Chem., 1998,
    37, 5786-5792.
  12. Resolution of Electron and Proton Transfer Events in the
    Electrochromism Associated with Quinone Reduction in Bacterial
    Reaction Centers, D. M. Tiede, L. Utschig, D. K. Hanson and
    D. M. Gallo, Photosynthesis Research, 1998, 55, 267-273.
  13. A New Metal-Binding Site in Photosynthetic Bacterial Reaction
    Centers that Modulates QA to QB Electron Transfer, L. M. Utschig,
    Y. Ohigashi, M. C. Thurnauer and D. M. Tiede, Biochem., 1998,
    37, 8278-8281.
  14. Transient W-Band EPR Study of Sequential Electron Transfer in
    Photosynthetic Bacterial Reaction Centers, J. Tang, L. M. Utschig,
    O. Poluektov and M. C. Thurnauer, J. Phys. Chem. B, 1999,
    103, 5145-5150.
  15. Magnetic Field Induced Orientation of Photosynthetic Reaction
    Centers as Revealed by Time-Resolved W-Band EPR of Spin-
    Correlated Radical Pairs, T. Berthold, M. Bechtold, U. Heinen,
    G. Link, O. Poluektov, L. Utschig, J. Tang, M. C. Thurnauer and
    G. Kothe, J. Phys. Chem. B, 1999, 103, 10733-10736.
  16. EPR Investigation of Cu2+-Substituted Photosynthetic Bacterial
    Reaction Centers: Evidence for Histidine Ligation at the Surface Metal
    Site, L. M. Utschig, O. Poluektov, D. M. Tiede and M. C. Thurnauer,
    Biochem., 2000, 39, 2961-2969.
  17. High-Frequency Approach to the Electron Spin-Polarization
    Effects Observed in the Photosynthetic Reaction Centers,
    O. G. Poluektov, L. M. Utschig, J. Tang, A. A. Dubinski,
    S. Schlesselman, and M. C. Thurnauer, Appl. Magn. Reson.,
    2001, 21, 311-323.
  18. Cu2+ Site in Photosynthetic Bacterial Reaction Centers from Rhodobacter
    sphaeroides, Rhodobacter capsulatus, and Rhodopseudomonas viridis,
    L. M. Utschig, O. Poluektov, S. Schlesselman, M. C. Thurnauer and
    D. M. Tiede, Biochem., 2001, 40, 6132-6141.
  19. Structure of the P+700A-1 Radical Pair Intermediate in Photosystem I
    by High Time Resolution Multifrequency Electron Paramagnetic
    Resonance: Analysis of Quantum Beat Oscillations, G. Link,
    T. Berthold, M. Bechtold, J-U. Weidner, E. Ohmes, J. Tang,
    O. Poluektov, L. Utschig, S. Schlesselman, M. C. Thurnauer and
    G. Kothe, J. Am. Chem. Soc., 2001, 123, 4211-4222.
  20. Electronic Structure of the P700 Special Pair from High-Frequency
    Electron Paramagnetic Resonance Spectroscopy, O. G. Poluektov,
    L. M. Utschig, S. L. Schlesselman, K. V. Lakshmi, G. W. Brudvig,
    G. Kothe, and M. C. Thurnauer, J. Phys. Chem. B, 2002, 106 (35),
    8911-8916.
  21. Probing Local Dynamics of the Photosynthetic Bacterial Reaction
    Center with a Cysteine Specific Spin Label, O. G. Poluektov,
    L. M. Utschig, S. Dalosto, and M. C. Thurnauer, J. Phys. Chem. B
    2003, 107 (25), 6239-6244.
  22. ENDOR of Spin-Correlated Radical Pairs in Photosynthesis at High
    Magnetic Field: A Tool for Mapping Electron Transfer Pathways,
    O. G. Poluektov, L. M. Utschig, A. A. Dubinskij, and M. C. Thurnauer
    J. Am. Chem. Soc. Comm., 2004, 126 (6), 1644-1645.
  23. Pulsed EPR/ENDOR Characterization of the Cu2+ Surface Site in
    Photosynthetic Bacterial Reaction Centers, L. M. Utschig,
    A. V. Astashkin, A. M. Raitsimring, M. C. Thurnauer, and
    O. G. Poleuktov, J. Phys. Chem. B, 2004, 108, 11150-11156.
  24. Metal Ion Modulated Electron Transfer in Photosynthetic Proteins,
    Acc. Chem. Res., 2004, 37, 439-447.
  25. Electron Transfer Pathways and Protein Response to Charge
    Separation in Photosynthetic Reaction Centers: Time-Resolved
    High-Field ENDOR of the Spin-Correlated Radical Pair P865+QA-,
    O. G. Poluektov, L. M. Utschig, A. A. Dubinskij, and M. C. Thurnauer,
    J. Am. Chem. Soc., 2005, 127 (11), 4049-4059.
  26. Bidirectional Electron Transfer in Photosystem I: Direct Evidence
    from High-Frequency time-Resolved EPR, O. G. Poluektov,
    S. V. Paschenko, L. M. Utschig, K. V. Lakshmi, and M. C. Thurnauer,
    J. Amer. Chem. Soc., 2005, 127 (34), 11910-11911.
  27. Structural Organization in Photosynthetic Proteins as Studied by
    High-Field EPR of Spin-Correlated Radical Pair States, G. Link,
    O. G. Poluektov, L. M. Utschig, J. Lalevee, T. Yago, J-U. Weidner,
    M. C. Thurnauer, and G. Kothe, Magn. Res. in Chem., 2005, 43,
    S103-S109.
  28. Low Temperature Interquinone Electron Transfer in Photosynthetic
    Reaction Centers from Rb. sphaeroides and Blc. viridis: Characterization
    of QB- States by High-Frequency EPR and ENDOR, L. M. Utschig,
    M. C. Thurnauer, D. Tiede, and O. G. Poluektov, Biochemistry, 2005,
    44 (43), 14131-14142.
  29. Spin-Correlated Radical Pairs: Differential Effects in High-Field ENDOR
    Spectra, A. A. Dubinskij, L. M. Utschig, and O. G. Poluektov, Appl.
    Magn. Reson., 2006, 30, 269-286.
  30. Exploring Hyperfine Interactions in Spin-Correlated Radical Pairs
    from Photosynthetic Proteins: High-Frequency ENDOR and Quantum
    Beat Oscillations, O. G. Poluektov, L. M. Utschig, M. C. Thurnauer,
    and G. Kothe, Appl. Magn. Reson., 2007, 31 (1-2), 123-143.
  31. Structure of the Charge Separated State P+865Q-A in the Photosynthetic
    Reaction Centers of Rhodobacter sphaeroides by Quantum Beat Oscillations
    and High-Field Electron Paramagnetic Resonance: Evidence for Light-Induced
    Q-A Reorientation, U. Heinen, L. M. Utschig, O. G. Poluektov, G. Link,
    E. Ohmes, and G. Kothe, J. Am. Chem. Soc., 2007, 129, 15935-15946.
  32. Protein Environments and Electron Transfer Processes Probed with
    High-Frequency ENDOR, O. G. Poluektov and L. M. Utschig, in The
    Purple Photosynthetic Bacteria
    , C. N. Hunter, F. Daldal,
    M. C. Thurnauer, and J. T. Beatty, Eds., Kluwer Publishers, In press 2008

 

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